NDR2 rabbit pAb

CAT: 0855-ES5289-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES5289-01Size:50 µL
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Background
Catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L., function:Involved in the regulation of structural processes in differentiating and mature neuronal cells., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family., similarity:Contains 1 AGC-kinase C-terminal domain., similarity:Contains 1 protein kinase domain., subcellular location:Associated with the actin cytoskeleton., subunit:Homodimeric S100B binds two molecules of STK38L (By similarity) . Interacts with MOB1 and MOB2., tissue specificity:Ubiquitously expressed with highest levels observed in the thymus.
Description
Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium. enzyme regulation: Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L. function: Involved in the regulation of structural processes in differentiating and mature neuronal cells. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. similarity: Contains 1 AGC-kinase C-terminal domain. similarity: Contains 1 protein kinase domain. subcellular location: Associated with the actin cytoskeleton. subunit: Homodimeric S100B binds two molecules of STK38L (By similarity). Interacts with MOB1 and MOB2. tissue specificity: Ubiquitously expressed with highest levels observed in the thymus.
UniProt
Q9Y2H1
Swiss Prot
Q9Y2H1
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from NDR2 . at AA range: 380-460
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000.IHC-p:1:50-300 ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
54kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
54kD
Fragment
IgG
Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton. Membrane. Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane.
Other Product Names
STK38L; KIAA0965; NDR2; Serine/threonine-protein kinase 38-like; NDR2 protein kinase; Nuclear Dbf2-related kinase 2
Gene ID (Human)
23012

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