ZNRF2 rabbit pAb

• Description:

  Domain: The RING-type zinc finger domain is required for E3 ligase activity. function: May play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. pathway: Protein modification; protein ubiquitination. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Contains 1 RING-type zinc finger. subcellular location: Present in presynaptic plasma membranes in neurons. subunit: Interacts with UBE2N. tissue specificity: Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.

• Synonyms:

  ZNRF2; RNF202; E3 ubiquitin-protein ligase ZNRF2; Protein Ells2; RING finger protein 202; Zinc/RING finger protein 2

• Gene ID:

  223082

• UniProt:

  Q8NHG8

• Cellular Locus:

  Endosome membrane ; Peripheral membrane protein. Lysosome membrane ; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane ; Peripheral membrane protein.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human ZNRF2. AA range:161-210

• Clonality:

  Polyclonal

• Validated Applications:

  IHC, IF, ELISA

• Stability:

  1 year

• Concentration:

  1 mg/mL

• Dilution:

  Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.