Cleaved-Factor Xa activated HC (I235) rabbit pAb

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Background

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway) . The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative sp

Description

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative sp

Product Name Alternative

F10; Coagulation factor X; Stuart factor; Stuart-Prower factor

UniProt

P00742

Swiss Prot

P00742

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human FA10. AA range:216-265

Target

FA10

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Buffer

-20°C/1 year

Molecular Weight

30kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

30kD

Fragment

IgG

Subcellular Location

Secreted.

Other Product Names

F10; Coagulation factor X; Stuart factor; Stuart-Prower factor

Gene ID (Human)

2159

UniProtKB · P00742

Coagulation factor X

FA10_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P00742
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: F10
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 3.4.21.6
Processing: Precursor
Secondary accessions: Q14340

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Blood coagulationHemostasis

Ligand

Calcium

PTM

Cleavage on pair of basic residuesDisulfide bondGamma-carboxyglutamic acidGlycoproteinHydroxylationZymogen

Disease

Disease variant

Domain

EGF-like domainRepeatSignal

Molecular function

HydrolaseProteaseSerine protease

Cellular component

Secreted

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Alternative Products

Catalog	Name
311168-01	Cleaved-Factor Xa activated HC (I235)
340319-01	Factor Xa activated HC, cleaved (I235) discontinued
L0126-01	Cleaved-Factor Xa activated HC (I235) Antibody
APRab08989-01	Cleaved-Factor Xa activated HC (I235) Rabbit Polyclonal Antibody
MBS2538423-01	Cleaved-Factor Xa activated HC (I235) Polyclonal Antibody
GTR18051863-01	Cleaved-Factor Xa activated HC (I235) rabbit pAb Antibody
E28G1957	Factor Xa activated HC (Cleaved I235) Rabbit Polyclonal Antibody
STJ90082	Anti-Cleaved-Factor Xa activated HC (I235) antibody
A00641	Anti-Cleaved-Factor Xa activated HC (I235) F10 Antibody
PA87634HU-01	Rabbit Anti-Human Cleaved-Factor Xa activated HC (I235) Polyclonal Antibody