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Cleaved-Integrin αV HC (K889) rabbit pAb

CAT: 0855-ES1065-01Size: 50 µLDry Ice: NoHazardous: No
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Background
Integrin subunit alpha V (ITGAV) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
Description
Integrin subunit alpha V (ITGAV) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015],
Product Name Alternative
ITGAV; MSK8; VNRA; Integrin alpha-V; Vitronectin receptor subunit alpha; CD antigen CD51
UniProt
P06756
Swiss Prot
P06756
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human ITGAV. AA range:840-889
Target
Integrin αV
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
95kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
95kD
Fragment
IgG
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion .
Other Product Names
ITGAV; MSK8; VNRA; Integrin alpha-V; Vitronectin receptor subunit alpha; CD antigen CD51
Gene ID (Human)
3685

UniProtKB · P06756

Integrin alpha-V

ITAV_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P06756
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITGAV
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A0AV67, B0LPF4, B7Z883, B7ZLX0, D3DPG8, E7EWZ6, Q53SK4, Q59EB7, Q6LD15
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Biological process

Cell adhesionHost-virus interaction

Cellular component

Cell junctionCell membraneMembrane

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoprotein

Disease

Disease variant

Molecular function

Host cell receptor for virus entryIntegrinReceptor

Domain

RepeatSignalTransmembraneTransmembrane helix

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