DOCK 2 rabbit pAb

• Background:

  The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]

• Description:

  The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016],

• Synonyms:

  DOCK2; KIAA0209; Dedicator of cytokinesis protein 2

• Gene ID:

  1794

• UniProt:

  Q92608

• Cellular Locus:

  Endomembrane system ; Peripheral membrane protein. Cytoplasm, cytoskeleton. Colocalizes with F-actin.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Synthesized peptide derived from the Internal region of human DOCK 2.

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  IHC, IF, ELISA

• Validated Applications:

  IHC, IF, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-2000 , Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Subcellular Location:

  Endomembrane system ; Peripheral membrane protein . Cytoplasm, cytoskeleton . Colocalizes with F-actin.

• Other Product Names:

  DOCK2; KIAA0209; Dedicator of cytokinesis protein 2

• Gene ID (Human):

  1794

• SwissProt (Human):

  Q92608