DOCK 2 rabbit pAb

CAT: 0855-ES5016-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES5016-01Size:50 µL
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Background
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
Description
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016],
UniProt
Q92608
Swiss Prot
Q92608
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from the Internal region of human DOCK 2.
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 , Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Endomembrane system ; Peripheral membrane protein . Cytoplasm, cytoskeleton . Colocalizes with F-actin.
Other Product Names
DOCK2; KIAA0209; Dedicator of cytokinesis protein 2
Gene ID (Human)
1794

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