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RAGE rabbit pAb

CAT: 0855-ES5013-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES5013-01Size:50 µL
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Background
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847) . [provided by RefSeq, May 2011]
Description
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID: 18089847). [provided by RefSeq, May 2011],
UniProt
Q15109
Swiss Prot
Q15109
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human RAGE. AA range:133-182
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
37kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
37kD
Fragment
IgG
Subcellular Location
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 10]: Cell membrane ; Single-pass type I membrane protein .
Other Product Names
AGER; RAGE; Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products
Gene ID (Human)
177

UniProtKB · Q15109

Advanced glycation end product-specific receptor

RAGE_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15109
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AGER
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A2BFI7, A6NKF0, A7Y2U9, B0V176, Q15279, Q3L1R4, Q3L1R5, Q3L1R6, Q3L1R7, Q3L1R8, Q3L1S0, Q86SN1, Q9H2X7, Q9Y3R3, V5R6A3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCell projectionEndosomeMembraneNucleusSecreted

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Biological process

DNA damageDNA repairDNA replicationInflammatory responsePhagocytosis

Molecular function

DNA-bindingReceptorRNA-binding

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

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