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Desmin (phospho Ser60) rabbit pAb

CAT: 0855-ES4992-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008]
Description
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008],
UniProt
P17661
Swiss Prot
P17661
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Desmin around the phosphorylation site of Ser60. AA range:26-75
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasmic
Other Product Names
DES; Desmin
Gene ID (Human)
1674

UniProtKB · P17661

Desmin

DESM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P17661
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DES
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q15787, Q549R7, Q549R8, Q549R9, Q8IZR1, Q8IZR6, Q8NES2, Q8NEU6, Q8TAC4, Q8TCX2, Q8TD99, Q9UHN5, Q9UJ80
Protein keywords

PTM

ADP-ribosylationMethylationPhosphoproteinUbl conjugation

Disease

CardiomyopathyDesmin-related myopathyDisease variantLimb-girdle muscular dystrophyMyofibrillar myopathy

Cellular component

Cell membraneCytoplasmIntermediate filamentMembraneNucleus

Domain

Coiled coil

Molecular function

Muscle protein

Technical term

Proteomics identificationReference proteome

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