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PAK2 (phospho-Ser20) rabbit pAb

CAT: 0855-ES14277-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES14277-01Size:50 µL
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UniProt
Q13153
Swiss Prot
Q13153
Reactivity
Human; Mouse
Immunogen
Synthesized phosho peptide around human PAK2 (Ser20)
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:1000-2000
Molecular Weight
60kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
60kD
Fragment
IgG
Subcellular Location
Cytoplasm . Cell junction, focal adhesion . Cell projection, lamellipodium . Cell membrane . Cell projection, ruffle membrane . Cell projection, invadopodium . Nucleus, nucleoplasm . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with RUFY3, F-actin and other core migration components in invadopodia at the cell periphery (PubMed:25766321) . Recruited to the cell membrane by interaction with CDC42 and RAC1. Recruited to focal adhesions upon activation. Colocalized with CIB1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Upon DNA damage, translocates to the nucleoplasm when phosphorylated at Thr-212 where is co-recruited with MORC2 on damaged chromatin (PubMed:23260667) . Localization to the centrosome does not depen

UniProtKB · Q13153

Serine/threonine-protein kinase PAK 1

PAK1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13153
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PAK1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
O75561, Q13567, Q32M53, Q32M54, Q86W79
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Molecular function

Allosteric enzymeKinaseSerine/threonine-protein kinaseTransferase

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisExocytosis

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell junctionCell membraneCell projectionChromosomeCytoplasmCytoskeletonMembraneNucleus

Disease

Disease variantEpilepsyIntellectual disability

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