PAK2 (phospho-Ser20) rabbit pAb

CAT: 0855-ES14277-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES14277-01Size:50 µL

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UniProt

Q13153

Swiss Prot

Q13153

Reactivity

Human; Mouse

Immunogen

Synthesized phosho peptide around human PAK2 (Ser20)

Clonality

Polyclonal

Source

Rabbit

Applications

Concentration

1 mg/ml

Dilution

WB 1:1000-2000

Molecular Weight

60kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

60kD

Fragment

IgG

Subcellular Location

Cytoplasm . Cell junction, focal adhesion . Cell projection, lamellipodium . Cell membrane . Cell projection, ruffle membrane . Cell projection, invadopodium . Nucleus, nucleoplasm . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with RUFY3, F-actin and other core migration components in invadopodia at the cell periphery (PubMed:25766321) . Recruited to the cell membrane by interaction with CDC42 and RAC1. Recruited to focal adhesions upon activation. Colocalized with CIB1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Upon DNA damage, translocates to the nucleoplasm when phosphorylated at Thr-212 where is co-recruited with MORC2 on damaged chromatin (PubMed:23260667) . Localization to the centrosome does not depen

UniProtKB · Q13153

Serine/threonine-protein kinase PAK 1

PAK1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q13153
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PAK1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 2.7.11.1
Processing: —
Secondary accessions: O75561, Q13567, Q32M53, Q32M54, Q86W79

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Molecular function

Allosteric enzymeKinaseSerine/threonine-protein kinaseTransferase

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisExocytosis

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell junctionCell membraneCell projectionChromosomeCytoplasmCytoskeletonMembraneNucleus

Disease

Disease variantEpilepsyIntellectual disability

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Alternative Products

Catalog	Name
APP1333-01	Phospho-PAK2 (Ser20) Rabbit pAb
E44H14517	PAK2 (phospho-Ser20) rabbit pAb
BS43219-01	Phospho-PAK2 (Ser20) Recombinant Rabbit mAb
SL3317R-01	Rabbit Anti-Phospho-PAK2 (Ser20) antibody
BT-AP11771-01	PAK2 (Phospho-Ser20) Rabbit Polyclonal Antibody
JOT-AP11771-01	PAK2(Phospho-Ser20) Rabbit Polyclonal Antibody
GTR17725391-01	Phospho-PAK2 (Ser20) Rabbit Polyclonal Antibody
GTR17832986	Phospho-PAK2 (Ser20) Rabbit Polyclonal Antibody (RBITC)
GTR18450168	Phospho-PAK2 (Ser20) Rabbit Polyclonal Antibody (BF350)
GTR18450113	Phospho-PAK2 (Ser20) Rabbit Polyclonal Antibody (BF647)