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DDX3 rabbit pAb

CAT: 0855-ES4985-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4985-01Size:50 µL
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Background
The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarit
Description
The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarit
Product Name Alternative
DDX3X; DBX; DDX3; ATP-dependent RNA helicase DDX3X; DEAD box protein 3; X-chromosomal; DEAD box, X isoform; Helicase-like protein 2; HLP2; DDX3Y; DBY; ATP-dependent RNA helicase DDX3Y; DEAD box protein 3, Y-chromosomal
UniProt
O00571/O15523
Swiss Prot
O00571/O15523
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from N-ternal human DDX3. AA range:14-63
Target
DDX3
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
73kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
73kD
Fragment
IgG
Subcellular Location
Cell membrane . Nucleus . Cytoplasm . Cytoplasm, Stress granule . Inflammasome . Cell projection, lamellipodium . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Shuttles between the nucleus and the cytosol (PubMed:15507209, PubMed:18636090, PubMed:29899501, PubMed:31575075, PubMed:30131165) . Exported from the nucleus partly through the XPO1/CRM1 system and partly through NXF1/TAP (PubMed:15507209, PubMed:18636090, PubMed:18596238, PubMed:31575075, PubMed:30131165) . Localizes to nuclear pores on the outer side of the nuclear membrane (PubMed:15507209) . In the cytosol, partly colocalizes with mitochondria (PubMed:20127681) . At G0, predominantly located in nucleus. In G1/S phase, predominantly cytoplasmic (PubMed:22034099) . During prophase/prometaphase, localizes in clos
Other Product Names
DDX3X; DBX; DDX3; ATP-dependent RNA helicase DDX3X; DEAD box protein 3; X-chromosomal; DEAD box, X isoform; Helicase-like protein 2; HLP2; DDX3Y; DBY; ATP-dependent RNA helicase DDX3Y; DEAD box protein 3, Y-chromosomal
Gene ID (Human)
1654/8653

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