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DDX1 rabbit pAb

CAT: 0855-ES16981-01Size: 50 µLDry Ice: NoHazardous: No
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Background
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin. [provided by RefSeq, Jul 2008]
Description
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin. [provided by RefSeq, Jul 2008],
UniProt
Q92499
Swiss Prot
Q92499
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human DDX1 AA range: 559-609
Target
DDX1
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Nucleus. Cytoplasm. Cytoplasmic granule. Cytoplasm, cytosol . Mitochondrion . Localized with MBNL1, TIAL1 and YBX1 in stress granules upon stress. Localized with CSTF2 in cleavage bodies. Forms large aggregates called DDX1 bodies. Relocalized into multiple foci (IR-induced foci or IRIF) after IR treatment, a process that depends on the presence of chromosomal DNA and/or RNA-DNA duplexes. Relocalized at sites of DNA double-strand breaks (DSBs) in an ATM-dependent manner after IR treatment. Colocalized with RELA in the nucleus upon TNF-alpha induction. Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264) . Colocalizes in the cytosol with DDX21, DHX36 and TICAM1. Colocalizes in the mitochondria with TICAM1 and
Gene ID (Human)
1653

UniProtKB · Q92499

ATP-dependent RNA helicase DDX1

DDX1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q92499
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DDX1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.6.4.13
Processing
—
Secondary accessions
B4DME8, B4DPN6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-bindingExonucleaseHelicaseHydrolaseNucleaseRNA-binding

Coding sequence diversity

Alternative splicing

Biological process

Antiviral defenseHost-virus interactionImmunityInnate immunitymRNA processingTranscriptionTranscription regulationtRNA processing

Ligand

ATP-bindingNucleotide-binding

Cellular component

CytoplasmMitochondrionNucleus

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