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DGK-θ rabbit pAb

CAT: 0855-ES4961-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4961-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008],
UniProt
P52824
Swiss Prot
P52824
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human DGKQ. AA range:691-740
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
101kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
101kD
Fragment
IgG
Subcellular Location
Cytoplasm . Cytoplasm, cytosol . Cell membrane . Cell junction, synapse . Cytoplasm, cytoskeleton . Nucleus . Nucleus speckle . Nucleus matrix . Translocates to the plasma membrane in response to steroid hormone receptor stimulation (PubMed:15632189) . Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH (PubMed:15632189) . Translocates to the nucleus in response to thrombin stimulation (Probable) . Association with the nuclear matrix is regulated by nerve growth factor (By similarity) . .
Other Product Names
DGKQ; DAGK4; Diacylglycerol kinase theta; DAG kinase theta; Diglyceride kinase theta; DGK-theta
Gene ID (Human)
1609

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