DGK-ζ Rabbit Polyclonal Antibody

• Background:

  The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010], catalytic activity:ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate., caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data., function:Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity., PTM:Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta., similarity:Belongs to the eukaryotic diacylglycerol kinase family., similarity:Contains 1 DAGKc domain., similarity:Contains 2 ANK repeats., similarity:Contains 2 phorbol-ester/DAG-type zinc fingers., subunit:Interacts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Isoform 2 forms a signaling complex with RASGRP1 and HRAS., tissue specificity:Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle.

• Product Name Alternative:

  DGKZ; DAGK6; Diacylglycerol kinase zeta; DAG kinase zeta; Diglyceride kinase zeta; DGK-zeta

• Gene Name:

  DGKZ

• Gene ID:

  8525

• Swiss Prot:

  Q13574

• Host:

  Rabbit

• Reactivity:

  Human, Rat, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  IHC, ICC/IF, ELISA

• Field of Research:

  Glycerolipid metabolism; Glycerophospholipid metabolism; Phosphatidylinositol signaling system

• Purification:

  Affinity purification

• Dilution:

  IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:10000-1:20000

• Form:

  Liquid

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

• Modification:

  Unmodified

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

• Isotype:

  IgG