CPLA2-ε rabbit pAb

CAT: 0855-ES4712-02Size: 100 µLDry Ice: NoHazardous: No

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CAT#:0855-ES4712-02Size:100 µL

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Background

Catalytic activity:Phosphatidylcholine + H (2) O = 1-acylglycerophosphocholine + a carboxylate., domain:The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca (2+) ., enzyme regulation:Stimulated by cytosolic Ca (2+) ., function:Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position., similarity:Contains 1 C2 domain., similarity:Contains 1 PLA2c domain., subcellular location:Translocates to lysosomal membranes in a calcium-dependent fashion.

Description

Catalytic activity: Phosphatidylcholine + H (2)O = 1-acylglycerophosphocholine + a carboxylate. Domain: The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca (2+). enzyme regulation: Stimulated by cytosolic Ca (2+). function: Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. similarity: Contains 1 C2 domain. similarity: Contains 1 PLA2c domain. subcellular location: Translocates to lysosomal membranes in a calcium-dependent fashion.

UniProt

Q3MJ16

Swiss Prot

Q3MJ16

Reactivity

Human; Rat; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human PLA2G4E. AA range:401-450

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Cytoplasm, cytosol . Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell membrane ; Peripheral membrane protein; Cytoplasmic side . Targeted to clathrin-independent endocytotic vesicles through binding to phosphoinositides, especially phosphatidylinositol 4,5-bisphosphates. .

Other Product Names

PLA2G4E; Cytosolic phospholipase A2 epsilon; cPLA2-epsilon; Phospholipase A2 group IVE

Gene ID (Human)

123745

UniProtKB · Q3MJ16

Cytosolic phospholipase A2 epsilon

PA24E_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q3MJ16
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PLA2G4E
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: cPLA2-epsilon
EC number: 3.1.1.4
Processing: —
Secondary accessions: B7WPN2, Q6ZSC0

Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Cellular component

Cell membraneCytoplasmEndosomeLysosomeMembrane

Molecular function

HydrolaseTransferase

Biological process

Lipid degradationLipid metabolism

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

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