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CPLA2 (phospho Ser505) rabbit pAb

CAT: 0855-ES6599-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca (2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Description
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca (2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015],
Product Name Alternative
PLA2G4A; CPLA2; PLA2G4; Cytosolic phospholipase A2; cPLA2; Phospholipase A2 group IVA
UniProt
P47712
Swiss Prot
P47712
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human c-PLA2 around the phosphorylation site of Ser505. AA range:471-520
Target
CPLA2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
110kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
110kD
Fragment
IgG
Subcellular Location
Cytoplasm . Golgi apparatus membrane . Nucleus envelope. Translocates to intracellular membranes in a calcium-dependent way. .
Other Product Names
PLA2G4A; CPLA2; PLA2G4; Cytosolic phospholipase A2; cPLA2; Phospholipase A2 group IVA
Gene ID (Human)
5321

UniProtKB · P47712

Cytosolic phospholipase A2

PA24A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P47712
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PLA2G4A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
cPLA2
EC number
—
Processing
—
Secondary accessions
B1AKG4, Q29R80
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CalciumLipid-bindingMetal-binding

Cellular component

CytoplasmGolgi apparatusMembraneNucleus

Disease

Disease variant

Biological process

Fatty acid biosynthesisFatty acid metabolismGlycerol metabolismLeukotriene biosynthesisLipid biosynthesisLipid degradationLipid metabolismPhospholipid degradationPhospholipid metabolismProstaglandin biosynthesisProstaglandin metabolism

Molecular function

Hydrolase

PTM

Isopeptide bondPhosphoproteinUbl conjugation

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