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C/EBP β rabbit pAb

CAT: 0855-ES4490-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4490-02Size:100 µL
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Background
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]
Description
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013],
UniProt
P17676
Swiss Prot
P17676
Reactivity
Human; Mouse; Rat; Pig
Immunogen
The antiserum was produced against synthesized peptide derived from human C/EBP-beta. AA range:201-250
Clonality
Polyclonal
Source
Rabbit
Applications
IF; WB; IHC; ELISA
Concentration
1 mg/ml
Dilution
IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
36kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
36kD
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasm . Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity) . .
Other Product Names
CEBPB; LAP; TCF5; PP9092; CCAAT/enhancer-binding protein beta; C/EBP beta; Liver activator protein; Nuclear factor NF-IL6; Transcription factor 5; TCF-5
Gene ID (Human)
1051

UniProtKB · P17676

CCAAT/enhancer-binding protein beta

CEBPB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P17676
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CEBPB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
C/EBP beta
EC number
—
Processing
—
Secondary accessions
A8K671, Q96IH2, Q9H4Z5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationGlycoproteinIsopeptide bondMethylationPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative initiation

Cellular component

CytoplasmNucleus

Biological process

DifferentiationTranscriptionTranscription regulation

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