C/EBP β (Acetyl Lys265) rabbit pAb

C/EBP β (Acetyl Lys265) rabbit pAb

• Description: Function: Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. PTM: Sumoylated by polymeric chains of SUMO2 or SUMO3. similarity: Belongs to the bZIP family. similarity: Belongs to the bZIP family. C/EBP subfamily. similarity: Contains 1 bZIP domain. subunit: Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha, delta and gamma. Interacts with TRIM28 and PTGES2. tissue specificity: Expressed at low levels in the lung, kidney and spleen.
• Synonyms: CCAAT/enhancer-binding protein beta (C/EBP beta;Liver activator protein;Nuclear factor NF-IL6;Transcription factor 5;TCF-5)
• Gene ID: 1051
• UniProt: P17676
• Cellular Locus: Nucleus. Cytoplasm. Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity)..
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthesized peptide derived from human C/EBP β (Acetyl Lys265)
• Clonality: Polyclonal
• Validated Applications: WB, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:1000-2000 ELISA 1:5000-20000
• Molecular Weight: 40kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.