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ACK rabbit pAb

CAT: 0855-ES4435-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4435-02Size:100 µL
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Background
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP) -stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Description
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008],
UniProt
Q07912
Swiss Prot
Q07912
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human ACK1. AA range:250-299
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
115kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
115kD
Fragment
IgG
Subcellular Location
Cell membrane . Nucleus . Endosome . Cell junction, adherens junction . Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasmic vesicle, clathrin-coated vesicle . Membrane, clathrin-coated pit . Cytoplasm, perinuclear region . Cytoplasm, cytosol . The Tyr-284 phosphorylated form is found both in the membrane and nucleus (By similarity) . Co-localizes with EGFR on endosomes (PubMed:20333297) . Nuclear translocation is CDC42-dependent (By similarity) . Detected in long filamentous cytosolic structures where it co-localizes with CTPS1 (By similarity) . .
Other Product Names
TNK2; ACK1; Activated CDC42 kinase 1; ACK-1; Tyrosine kinase non-receptor protein 2
Gene ID (Human)
10188

UniProtKB · Q07912

Activated CDC42 kinase 1

ACK1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q07912
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TNK2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
ACK-1
EC number
2.7.10.2, 2.7.11.1
Processing
—
Secondary accessions
Q6ZMQ0, Q8N6U7, Q96H59
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Cellular component

Cell junctionCell membraneCoated pitCytoplasmCytoplasmic vesicleEndosomeMembraneNucleus

Biological process

Endocytosis

Molecular function

KinaseSerine/threonine-protein kinaseTransferaseTyrosine-protein kinase

PTM

MethylationPhosphoproteinUbl conjugation

Domain

SH3 domain

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