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CD13 rabbit pAb

CAT: 0855-ES4309-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4309-02Size:100 µL
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Background
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is
Description
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is
Product Name Alternative
ANPEP; APN; CD13; PEPN; Aminopeptidase N; AP-N; hAPN; Alanyl aminopeptidase; Aminopeptidase M; AP-M; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; gp150; CD13
UniProt
P15144
Swiss Prot
P15144
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from Aminopeptidase N at AA range: 881-930
Target
CD13
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
110kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
110kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type II membrane protein . Also found as a soluble form. .
Other Product Names
ANPEP; APN; CD13; PEPN; Aminopeptidase N; AP-N; hAPN; Alanyl aminopeptidase; Aminopeptidase M; AP-M; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; gp150; CD13
Gene ID (Human)
290

UniProtKB · P15144

Aminopeptidase N

AMPN_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P15144
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ANPEP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
AP-N, hAPN
EC number
3.4.11.2
Processing
—
Secondary accessions
Q16728, Q6GT90, Q8IUK3, Q8IVH3, Q9UCE0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

AminopeptidaseDevelopmental proteinHost cell receptor for virus entryHydrolaseMetalloproteaseProteaseReceptor

Biological process

AngiogenesisDifferentiationHost-virus interaction

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinSulfation

Ligand

Metal-bindingZinc

Domain

Signal-anchorTransmembraneTransmembrane helix

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