CD133 rabbit pAb

CAT: 0855-ES3922-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES3922-01Size:50 µL
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Background
This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Description
This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],
Product Name Alternative
PROM1; Prominin-1; Antigen AC133; Prominin-like protein 1; CD133
UniProt
O43490
Swiss Prot
O43490
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from the N-terminal region of human PROM1. AA range:41-90
Target
CD133
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
100kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
100kD
Fragment
IgG
Subcellular Location
Apical cell membrane ; Multi-pass membrane protein . Cell projection, microvillus membrane ; Multi-pass membrane protein . Cell projection, cilium, photoreceptor outer segment . Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Found in extracellular membrane particles in various body fluids such as cerebrospinal fluid, saliva, seminal fluid and urine.
Other Product Names
PROM1; Prominin-1; Antigen AC133; Prominin-like protein 1; CD133
Gene ID (Human)
8842

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