OAS2 rabbit pAb

• Background:

  2'-5'-oligoadenylate synthetase 2 (OAS2) Homo sapiens This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As) . These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

• Description:

  2'-5'-oligoadenylate synthetase 2 (OAS2) Homo sapiens This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2', 5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],

• UniProt:

  P29728

• Swiss Prot:

  P29728

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  The antiserum was produced against synthesized peptide derived from the N-terminal region of human OAS2. AA range:61-110

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; IHC; IF; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight:

  82kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  82kD

• Fragment:

  IgG

• Subcellular Location:

  Cytoplasm . Cytoplasm, perinuclear region .

• Other Product Names:

  OAS2; 2'-5'-oligoadenylate synthase 2; (2-5') oligo (A) synthase 2; 2-5A synthase 2; p69 OAS / p71 OAS; p69OAS / p71OAS

• Gene ID (Human):

  4939