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CD63 rabbit pAb

CAT: 0855-ES4255-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4255-02Size:100 µL
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Background
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]
Description
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012],
Product Name Alternative
CD63; MLA1; TSPAN30; CD63 antigen; Granulophysin; Lysosomal-associated membrane protein 3; LAMP-3; Melanoma-associated antigen ME491; OMA81H; Ocular melanoma-associated antigen; Tetraspanin-30; Tspan-30; CD63
UniProt
P08962
Swiss Prot
P08962
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human CD63. AA range:121-170
Target
CD63
Clonality
Polyclonal
Source
Rabbit
Applications
IF; WB; IHC; ELISA
Concentration
1 mg/ml
Dilution
IF: 1:50-200 Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
26,35-65(kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
26,35-65 (kD
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Late endosome membrane ; Multi-pass membrane protein . Endosome, multivesicular body . Melanosome . Secreted, extracellular exosome . Cell surface . Also found in Weibel-Palade bodies of endothelial cells (PubMed:10793155) . Located in platelet dense granules (PubMed:7682577) . Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (PubMed:21962903) . .
Other Product Names
CD63; MLA1; TSPAN30; CD63 antigen; Granulophysin; Lysosomal-associated membrane protein 3; LAMP-3; Melanoma-associated antigen ME491; OMA81H; Ocular melanoma-associated antigen; Tetraspanin-30; Tspan-30; CD63
Gene ID (Human)
967

UniProtKB · P08962

CD63 antigen

CD63_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08962
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD63
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
F8VZE2, Q5TZP3, Q8N6Z9, Q9UCG6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneEndosomeLysosomeMembraneSecreted

PTM

GlycoproteinLipoproteinPalmitate

Biological process

Protein transportTransport

Domain

TransmembraneTransmembrane helix

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