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ApoA-I rabbit pAb

CAT: 0855-ES4169-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015]
Description
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015],
Product Name Alternative
APOA1; Apolipoprotein A-I; Apo-AI; ApoA-I; Apolipoprotein A1
UniProt
P02647
Swiss Prot
P02647
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human APOA1. AA range:81-130
Target
ApoA-I
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
31kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
31kD
Fragment
IgG
Subcellular Location
Secreted.
Other Product Names
APOA1; Apolipoprotein A-I; Apo-AI; ApoA-I; Apolipoprotein A1
Gene ID (Human)
335

UniProtKB · P02647

Apolipoprotein A-I

APOA1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P02647
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
APOA1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Apo-AI, ApoA-I
EC number
—
Processing
Precursor
Secondary accessions
A8K866, Q6LDN9, Q6Q785, Q9UCS8, Q9UCT8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Cellular component

AmyloidHDLSecreted

Disease

AmyloidosisAtherosclerosisDisease variantNeuropathy

Biological process

Cholesterol metabolismLipid metabolismLipid transportSteroid metabolismSterol metabolismTransport

PTM

GlycationGlycoproteinLipoproteinNitrationOxidationPalmitatePhosphoprotein

Domain

RepeatSignal

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