CD207 rabbit pAb

CAT: 0855-ES4005-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES4005-01Size:50 µL
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Background
The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]
Description
The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010],
Product Name Alternative
CD207; CLEC4K; C-type lectin domain family 4 member K; Langerin; CD207
UniProt
Q9UJ71
Swiss Prot
Q9UJ71
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human CD207. AA range:61-110
Target
CD207
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
38kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
38kD
Fragment
IgG
Subcellular Location
Membrane ; Single-pass type II membrane protein . Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
Other Product Names
CD207; CLEC4K; C-type lectin domain family 4 member K; Langerin; CD207
Gene ID (Human)
50489

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