NPRL2 rabbit pAb

• Background:

  Function:Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs., similarity:Belongs to the NPR2 family., subunit:Interacts with PDPK1., tissue specificity:Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.

• Description:

  Function: Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs. similarity: Belongs to the NPR2 family. subunit: Interacts with PDPK1. tissue specificity: Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.

• UniProt:

  Q8WTW4

• Swiss Prot:

  Q8WTW4

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Synthesized peptide derived from the C-terminal region of human NPRL2.

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight:

  43kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  43kD

• Fragment:

  IgG

• Subcellular Location:

  Lysosome membrane . Localization to lysosomes is amino acid-independent. .

• Other Product Names:

  NPRL2; TUSC4; Nitrogen permease regulator 2-like protein; NPR2-like protein; Gene 21 protein; G21 protein; Tumor suppressor candidate 4

• Gene ID (Human):

  10641