NPRL2 rabbit pAb

CAT: 0855-ES3816-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES3816-01Size:50 µL
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Background
Function:Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs., similarity:Belongs to the NPR2 family., subunit:Interacts with PDPK1., tissue specificity:Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.
Description
Function: Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs. similarity: Belongs to the NPR2 family. subunit: Interacts with PDPK1. tissue specificity: Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.
Product Name Alternative
NPRL2; TUSC4; Nitrogen permease regulator 2-like protein; NPR2-like protein; Gene 21 protein; G21 protein; Tumor suppressor candidate 4
UniProt
Q8WTW4
Swiss Prot
Q8WTW4
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from the C-terminal region of human NPRL2.
Target
NPRL2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
43kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
43kD
Fragment
IgG
Subcellular Location
Lysosome membrane . Localization to lysosomes is amino acid-independent. .
Other Product Names
NPRL2; TUSC4; Nitrogen permease regulator 2-like protein; NPR2-like protein; Gene 21 protein; G21 protein; Tumor suppressor candidate 4
Gene ID (Human)
10641

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