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EEA1 rabbit pAb

CAT: 0855-ES3758-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES3758-02Size:100 µL
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Background
Disease:Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases., domain:The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate., function:Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking., similarity:Contains 1 C2H2-type zinc finger., similarity:Contains 1 FYVE-type zinc finger., subunit:Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding.
Description
Disease: Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases. Domain: The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate. function: Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. similarity: Contains 1 C2H2-type zinc finger. similarity: Contains 1 FYVE-type zinc finger. subunit: Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding.
Product Name Alternative
EEA1; ZFYVE2; Early endosome antigen 1; Endosome-associated protein p162; Zinc finger FYVE domain-containing protein 2
UniProt
Q15075
Swiss Prot
Q15075
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human EEA1. AA range:205-254
Target
EEA1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
162kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
162kD
Fragment
IgG
Subcellular Location
Cytoplasm. Early endosome membrane; Peripheral membrane protein.
Other Product Names
EEA1; ZFYVE2; Early endosome antigen 1; Endosome-associated protein p162; Zinc finger FYVE domain-containing protein 2
Gene ID (Human)
8411

UniProtKB · Q15075

Early endosome antigen 1

EEA1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15075
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EEA1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q14221
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Domain

Coiled coilZinc-finger

Cellular component

CytoplasmEndosomeMembrane

Ligand

Metal-bindingZinc

PTM

Phosphoprotein

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