EEA1 rabbit pAb

• Background:

  Disease:Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases., domain:The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate., function:Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking., similarity:Contains 1 C2H2-type zinc finger., similarity:Contains 1 FYVE-type zinc finger., subunit:Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding.

• Description:

  Disease: Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases. Domain: The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate. function: Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. similarity: Contains 1 C2H2-type zinc finger. similarity: Contains 1 FYVE-type zinc finger. subunit: Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding.

• UniProt:

  Q15075

• Swiss Prot:

  Q15075

• Reactivity:

  Human; Mouse

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human EEA1. AA range:205-254

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight:

  162kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  162kD

• Fragment:

  IgG

• Subcellular Location:

  Cytoplasm. Early endosome membrane; Peripheral membrane protein.

• Other Product Names:

  EEA1; ZFYVE2; Early endosome antigen 1; Endosome-associated protein p162; Zinc finger FYVE domain-containing protein 2

• Gene ID (Human):

  8411