UBE3C rabbit pAb

• Background:

  Function:E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo., miscellaneous:A cysteine residue is required for ubiquitin-thioester formation., pathway:Protein modification; protein ubiquitination., similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain., similarity:Contains 1 IQ domain., subunit:Interacts with 26S proteasomes. Binds CAND2., tissue specificity:Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas.

• Description:

  Function: E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. miscellaneous: A cysteine residue is required for ubiquitin-thioester formation. pathway: Protein modification; protein ubiquitination. similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. similarity: Contains 1 IQ domain. subunit: Interacts with 26S proteasomes. Binds CAND2. tissue specificity: Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas.

• Synonyms:

  UBE3C; KIAA0010; KIAA10; Ubiquitin-protein ligase E3C; HectH2

• Gene ID:

  148581

• UniProt:

  Q15386

• Cellular Locus:

  Proteasome complex,intracellular,nucleus,cytoplasm,

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse,

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized peptide derived from the Internal region of human UBE3C.

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Validated Applications:

  WB, ELISA

• Stability:

  -20°C / 1 year

• Concentration:

  1 mg/mL

• Dilution:

  Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

• Molecular Weight:

  125kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  125kD

• Subcellular Location:

  Proteasome complex, intracellular, nucleus, cytoplasm

• Other Product Names:

  UBE3C; KIAA0010; KIAA10; Ubiquitin-protein ligase E3C; HectH2

• Gene ID (Human):

  148581

• SwissProt (Human):

  Q15386