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UBE2D2 rabbit pAb

CAT: 0855-ES3665-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES3665-02Size:100 µL
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Background
Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub) -proteasome system (UPS) . An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5) . Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Description
Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013],
Product Name Alternative
UBE2D2; UBC4; UBC5B; UBCH4; UBCH5B; Ubiquitin-conjugating enzyme E2 D2; Ubiquitin carrier protein D2; Ubiquitin-conjugating enzyme E2 (17) KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; Ubiquitin-protein ligase D2
UniProt
P62837
Swiss Prot
P62837
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human UBE2D2. AA range:98-147
Target
UBE2D2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
17kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
17kD
Fragment
IgG
Subcellular Location
Ubiquitin ligase complex, nucleoplasm, cytosol, protein complex, extracellular exosome
Other Product Names
UBE2D2; UBC4; UBC5B; UBCH4; UBCH5B; Ubiquitin-conjugating enzyme E2 D2; Ubiquitin carrier protein D2; Ubiquitin-conjugating enzyme E2 (17) KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; Ubiquitin-protein ligase D2
Gene ID (Human)
7322

UniProtKB · P62837

Ubiquitin-conjugating enzyme E2 D2

UB2D2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P62837
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
UBE2D2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.23
Processing
—
Secondary accessions
D3DQC9, P51669, Q3MN78, Q96RP6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

Transferase

Biological process

Ubl conjugation pathway

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