TP53INP1 rabbit pAb

• Background:

  Function:In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis., induction:By adriamycin, gamma irradiation and H (2) O (2), in a p53-dependent way. At lower levels by ultraviolet irradiation., subcellular location:Concentrated in PML/POD/ND10 nuclear bodies., subunit:Interacts with TP53 and HIPK2., tissue specificity:Ubiquitously expressed.

• Description:

  Function: In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. induction: By adriamycin, gamma irradiation and H (2)O (2), in a p53-dependent way. At lower levels by ultraviolet irradiation. subcellular location: Concentrated in PML/POD/ND10 nuclear bodies. subunit: Interacts with TP53 and HIPK2. tissue specificity: Ubiquitously expressed.

• Synonyms:

  TP53INP1; P53DINP1; SIP; Tumor protein p53-inducible nuclear protein 1; Stress-induced protein; p53-dependent damage-inducible nuclear protein 1; p53DINP1

• Gene ID:

  94241

• UniProt:

  Q96A56

• Cellular Locus:

  Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse,

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human TP53INP1. AA range:171-220

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, IHC, IF, ELISA

• Validated Applications:

  WB, IHC, IF, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

• Molecular Weight:

  27kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  27 kD

• Subcellular Location:

  Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.

• Other Product Names:

  TP53INP1; P53DINP1; SIP; Tumor protein p53-inducible nuclear protein 1; Stress-induced protein; p53-dependent damage-inducible nuclear protein 1; p53DINP1

• Gene ID (Human):

  94241

• SwissProt (Human):

  Q96A56