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TP53INP1 rabbit pAb

CAT: 0855-ES3629-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES3629-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Function:In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis., induction:By adriamycin, gamma irradiation and H (2) O (2), in a p53-dependent way. At lower levels by ultraviolet irradiation., subcellular location:Concentrated in PML/POD/ND10 nuclear bodies., subunit:Interacts with TP53 and HIPK2., tissue specificity:Ubiquitously expressed.
Description
Function: In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. induction: By adriamycin, gamma irradiation and H (2)O (2), in a p53-dependent way. At lower levels by ultraviolet irradiation. subcellular location: Concentrated in PML/POD/ND10 nuclear bodies. subunit: Interacts with TP53 and HIPK2. tissue specificity: Ubiquitously expressed.
UniProt
Q96A56
Swiss Prot
Q96A56
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human TP53INP1. AA range:171-220
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
27kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
27kD
Fragment
IgG
Subcellular Location
Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.
Other Product Names
TP53INP1; P53DINP1; SIP; Tumor protein p53-inducible nuclear protein 1; Stress-induced protein; p53-dependent damage-inducible nuclear protein 1; p53DINP1
Gene ID (Human)
94241

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