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SMG7 rabbit pAb

CAT: 0855-ES3466-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES3466-01Size:50 µL
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Background
SMG7, nonsense mediated mRNA decay factor (SMG7) Homo sapiens This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD) ; a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]
Description
SMG7, nonsense mediated mRNA decay factor (SMG7) Homo sapiens This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011],
UniProt
Q92540
Swiss Prot
Q92540
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human SMG7. AA range:521-570
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
127kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
127kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. .
Other Product Names
SMG7; C1orf16; EST1C; KIAA0250; Protein SMG7; EST1-like protein C; SMG-7 homolog; hSMG-7
Gene ID (Human)
9887

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