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PP2A-Cα rabbit pAb

CAT: 0855-ES3248-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES3248-02Size:100 µL
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Background
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]
Description
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008],
UniProt
P67775
Swiss Prot
P67775
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human PP2A-alpha. AA range:260-309
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
35kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
35kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . Chromosome, centromere . Cytoplasm, cytoskeleton, spindle pole . In prometaphase cells, but not in anaphase cells, localizes at centromeres (PubMed:16541025) . During mitosis, also found at spindle poles (PubMed:16541025) . Centromeric localization requires the presence of SGO2 (By similarity) . .
Other Product Names
PPP2CA; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A-alpha; Replication protein C; RP-C
Gene ID (Human)
5515

UniProtKB · P67775

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

PP2AA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P67775
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PPP2CA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PP2A-alpha
EC number
3.1.3.16
Processing
—
Secondary accessions
P05323, P13197
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CentromereChromosomeCytoplasmCytoskeletonNucleus

Disease

Disease variantIntellectual disability

Molecular function

HydrolaseProtein phosphatase

Ligand

IronManganeseMetal-bindingZinc

Biological process

Meiosis

PTM

MethylationPhosphoproteinUbl conjugation

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