PP2A-B55-β rabbit pAb

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PP2A-B55-β rabbit pAb

CAT:

855-ES6715-01

Size:

50 μL

Price:

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For price, please contact [email protected].

PP2A-B55-β rabbit pAb

Description: Protein phosphatase 2 regulatory subunit Bbeta (PPP2R2B) Homo sapiens The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isofor
Synonyms: PPP2R2B; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; PP2A subunit B isoform B55-beta; PP2A subunit B isoform PR55-beta; PP2A subunit B isoform R2-beta; PP2A subunit B isoform beta
Gene ID: 5521
UniProt: Q00005
Cellular Locus: [Isoform 1]: Cytoplasm. Cytoplasm, cytoskeleton. Membrane.; [Isoform 2]: Cytoplasm. Mitochondrion. Mitochondrion outer membrane. Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity (By similarity)..
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from PP2A-B55-β . at AA range: 90-170
Clonality: Polyclonal
Validated Applications: WB, IHC
Stability: 1 year
Concentration: 1 mg/mL
Dilution: WB 1:500-2000;IHC-p 1:50-300
Molecular Weight: 51kD
Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

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