RegisterLogin

PMS2 rabbit pAb

CAT: 0855-ES3241-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES3241-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA (X) 2E (X) 4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome
Description
The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA (X)2E (X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome
UniProt
P54278
Swiss Prot
P54278
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human PMS2. AA range:461-510
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
85kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
85kD
Fragment
IgG
Subcellular Location
Nucleus .
Other Product Names
PMS2; PMSL2; Mismatch repair endonuclease PMS2; DNA mismatch repair protein PMS2; PMS1 protein homolog 2
Gene ID (Human)
5395

Related Products

CatalogName
ES6634-01PMS2/PMS2CL rabbit pAb
ELKP470PMS2-GFP
ES3240-01PMS1 rabbit pAb
ES14051-01PMS2L rabbit pAb
ES4666-01RAB3IP rabbit pAb
ES20751-01Gab1 Rabbit rabbit pAb
ES20703-01JAK2 Rabbit rabbit pAb
ES20758-01ERK1 Rabbit rabbit pAb
ES20599-01VEGF Rabbit rabbit pAb
ES20825-01ATG7 Rabbit rabbit pAb

Alternative Products

CatalogName
NBP3-23590-100ugRabbit Monoclonal PMS2 Antibody (PMS2/8224R)
NBP3-07615-100ugRabbit Monoclonal PMS2 Antibody (PMS2/4373R)
NBP3-20297-20ugRabbit Monoclonal PMS2 Antibody (PMS2/8374R)
MBS8549176-01PMS2 Rabbit pAb
MBS9469492-01PMS2 Rabbit mAb
NBP3-20968PCPRabbit Monoclonal PMS2 Antibody (PMS2/8374R) [PerCP]
NBP3-24032FRabbit Monoclonal PMS2 Antibody (PMS2/8224R) [FITC]
NBP3-20968HRabbit Monoclonal PMS2 Antibody (PMS2/8374R) [HRP]

Popular Products