PGE synthase rabbit pAb

PGE synthase rabbit pAb

• Description: Prostaglandin E synthase (PTGES) Homo sapiens The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory Cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008],
• Synonyms: PTGES; MGST1L1; MPGES1; PGES; PIG12; Prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
• Gene ID: 9536
• UniProt: O14684
• Cellular Locus: Membrane ; Multi-pass membrane protein. Cytoplasm, perinuclear region. Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment..
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: The antiserum was produced against synthesized peptide derived from human PGE synthase. AA range:30-79
• Clonality: Polyclonal
• Validated Applications: WB, ELISA, IHC
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
• Molecular Weight: 17kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.