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Fatty Acid Synthase rabbit pAb

CAT: 0855-ES2333-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2333-01Size:50 µL
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Background
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
Description
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008],
Product Name Alternative
FASN; FAS; Fatty acid synthase
UniProt
P49327
Swiss Prot
P49327
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Fatty Acid Synthase. AA range:1478-1527
Target
Fatty Acid Synthase
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
IHC-p: 100-300.Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
273kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
273kD
Fragment
IgG
Subcellular Location
Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Other Product Names
FASN; FAS; Fatty acid synthase
Gene ID (Human)
2194

UniProtKB · P49327

Fatty acid synthase

FAS_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P49327
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FASN
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.1.85
Processing
—
Secondary accessions
Q13479, Q16702, Q4LE83, Q6P4U5, Q6SS02, Q969R1, Q96C68, Q96IT0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphopantetheinePhosphoproteinS-nitrosylationUbl conjugation

Cellular component

Cytoplasm

Biological process

Fatty acid biosynthesisFatty acid metabolismLipid biosynthesisLipid metabolism

Molecular function

HydrolaseLyaseMultifunctional enzymeOxidoreductaseTransferase

Ligand

NADNADPPyridoxal phosphate

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