PARD3A rabbit pAb

CAT: 0855-ES3149-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES3149-01Size:50 µL

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Background

This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

Description

Product Name Alternative

PARD3; PAR3; PAR3A; Partitioning defective 3 homolog; PAR-3; PARD-3; Atypical PKC isotype-specific-interacting protein; ASIP; CTCL tumor antigen se2-5; PAR3-alpha

UniProt

Q8TEW0

Swiss Prot

Q8TEW0

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human PARD3. AA range:1141-1190

Target

PARD3A

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Buffer

-20°C/1 year

Molecular Weight

151kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

151kD

Fragment

IgG

Subcellular Location

Cytoplasm . Endomembrane system . Cell junction . Cell junction, tight junction . Cell junction, adherens junction . Cell membrane . Cytoplasm, cell cortex . Cytoplasm, cytoskeleton . Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II. Colocalized with SIRT2 in internode region of myelin sheath (By similarity) . Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. .

Other Product Names

PARD3; PAR3; PAR3A; Partitioning defective 3 homolog; PAR-3; PARD-3; Atypical PKC isotype-specific-interacting protein; ASIP; CTCL tumor antigen se2-5; PAR3-alpha

Gene ID (Human)

56288

UniProtKB · Q8TEW0

Partitioning defective 3 homolog

PARD3_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q8TEW0
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PARD3
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: PAR-3, PARD-3
EC number: —
Processing: —
Secondary accessions: F5H5T0, Q5T2U1, Q5VUA2, Q5VUA3, Q5VWV0, Q5VWV1, Q5VWV3, Q5VWV4, Q5VWV5, Q6IQ47, Q8TCZ9, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Biological process

Cell cycleCell divisionDifferentiation

Cellular component

Cell junctionCell membraneCytoplasmCytoskeletonMembraneTight junction

Domain

Coiled coilRepeat

Disease

Disease variant

Ligand

Lipid-binding

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