PAR4 rabbit pAb

CAT: 0855-ES3147-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES3147-01Size:50 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008]
Description
The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008],
UniProt
Q96IZ0
Swiss Prot
Q96IZ0
Reactivity
Human; Mouse; Rat; Cow
Immunogen
The antiserum was produced against synthesized peptide derived from human Prostate Apoptosis Response protein-4. AA range:291-340
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
36kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
36kD
Fragment
IgG
Subcellular Location
Cytoplasm. Nucleus. Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity) . Nuclear localization includes nucleoplasm and PML nuclear bodies. .
Other Product Names
PAWR; PAR4; PRKC apoptosis WT1 regulator protein; Prostate apoptosis response 4 protein; Par-4
Gene ID (Human)
5074

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