PAR4 rabbit pAb

• Background :

  The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008]

• Description :

  The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008],

• UniProt :

  Q96IZ0

• Swiss Prot :

  Q96IZ0

• Reactivity :

  Human; Mouse; Rat; Cow

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human Prostate Apoptosis Response protein-4. AA range:291-340

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

• Molecular Weight :

  36kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  36kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm. Nucleus. Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity) . Nuclear localization includes nucleoplasm and PML nuclear bodies. .

• Other Product Names :

  PAWR; PAR4; PRKC apoptosis WT1 regulator protein; Prostate apoptosis response 4 protein; Par-4

• Gene ID (Human) :

  5074