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P53RFP rabbit pAb

CAT: 0855-ES3129-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES3129-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Caution:Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family., domain:The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme., function:E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a TP53/p53-dependent but caspase-independent mechanism., pathway:Protein modification; protein ubiquitination., PTM:Auto-ubiquitinated., similarity:Belongs to the RBR family. RNF144 subfamily., similarity:Contains 1 IBR-type zinc finger., similarity:Contains 2 RING-type zinc fingers., subunit:Interacts with UBE2L3, UBE2L6 and LCMT2., tissue specificity:Broadly expressed, with lowest levels in brain, spleen and thymus.
Description
Caution: Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family. Domain: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme. function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a TP53/p53-dependent but caspase-independent mechanism. pathway: Protein modification; protein ubiquitination. PTM: Auto-ubiquitinated. similarity: Belongs to the RBR family. RNF144 subfamily. similarity: Contains 1 IBR-type zinc finger. similarity: Contains 2 RING-type zinc fingers. subunit: Interacts with UBE2L3, UBE2L6 and LCMT2. tissue specificity: Broadly expressed, with lowest levels in brain, spleen and thymus.
Product Name Alternative
RNF144B; IBRDC2; P53RFP; E3 ubiquitin-protein ligase RNF144B; IBR domain-containing protein 2; RING finger protein 144B; p53-inducible RING finger protein
UniProt
Q7Z419
Swiss Prot
Q7Z419
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from the Internal region of human p53RFP.
Target
P53RFP
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
35kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
35kD
Fragment
IgG
Subcellular Location
Mitochondrion membrane ; Single-pass membrane protein . Cytoplasm . Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.
Other Product Names
RNF144B; IBRDC2; P53RFP; E3 ubiquitin-protein ligase RNF144B; IBR domain-containing protein 2; RING finger protein 144B; p53-inducible RING finger protein
Gene ID (Human)
255488

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