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IKKγ rabbit pAb

CAT: 0855-ES2605-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2605-02Size:100 µL
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Background
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016]
Description
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016],
Product Name Alternative
IKBKG; FIP3; NEMO; NF-kappa-B essential modulator; NEMO; FIP-3; IkB kinase-associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF
UniProt
Q9Y6K9
Swiss Prot
Q9Y6K9
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human IKK-gamma. AA range:51-100
Target
IKKγ
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
43kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
43kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress. .
Other Product Names
IKBKG; FIP3; NEMO; NF-kappa-B essential modulator; NEMO; FIP-3; IkB kinase-associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF
Gene ID (Human)
8517

UniProtKB · Q9Y6K9

NF-kappa-B essential modulator

NEMO_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y6K9
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IKBKG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
NEMO
EC number
—
Processing
—
Secondary accessions
Q7LBY6, Q7Z7F1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Domain

Coiled coilZinc-finger

Cellular component

CytoplasmNucleus

Disease

Disease variantEctodermal dysplasiaOsteopetrosis

PTM

Disulfide bondIsopeptide bondPhosphoproteinUbl conjugation

Biological process

DNA damageHost-virus interactionTranscriptionTranscription regulation

Ligand

Metal-bindingZinc

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