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FAST rabbit pAb

CAT: 0855-ES2328-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2328-02Size:100 µL
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Background
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008],
Product Name Alternative
FASTK; Fas-activated serine/threonine kinase; FAST kinase
UniProt
Q14296
Swiss Prot
Q14296
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human FAST. AA range:361-410
Target
FAST
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
61kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
61kD
Fragment
IgG
Subcellular Location
[Isoform 4]: Mitochondrion matrix . Colocalizes with mitochondrial RNA granules. .
Other Product Names
FASTK; Fas-activated serine/threonine kinase; FAST kinase
Gene ID (Human)
10922

UniProtKB · Q14296

Fas-activated serine/threonine kinase

FASTK_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q14296
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FASTK
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
FAST kinase
EC number
2.7.11.1, 2.7.11.8
Processing
—
Secondary accessions
A8K867, F8VTW9, Q59EM8, Q8IVA0
Protein keywords

Coding sequence diversity

Alternative initiationAlternative splicing

Biological process

Apoptosis

Ligand

ATP-bindingNucleotide-binding

Molecular function

KinaseRNA-bindingSerine/threonine-protein kinaseTransferase

Cellular component

Mitochondrion

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

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