Products for Research Use Only
RegisterLogin

FAS-L rabbit pAb

CAT: 0855-ES2327-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES2327-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE) . Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]
Description
This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014],
Product Name Alternative
FASLG; APT1LG1; CD95L; FASL; TNFSF6; Tumor necrosis factor ligand superfamily member 6; Apoptosis antigen ligand; APTL; CD95 ligand; CD95-L; Fas antigen ligand; Fas ligand; FasL; CD antigen CD178
UniProt
P48023
Swiss Prot
P48023
Reactivity
Human; Mouse; Pig
Immunogen
The antiserum was produced against synthesized peptide derived from human FAS ligand. AA range:101-150
Target
FAS-L
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
33kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
33kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type II membrane protein . Cytoplasmic vesicle lumen . Lysosome lumen . Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290) . Colocalizes with the SPPL2A protease at the cell membrane (PubMed:17557115) . .; [Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted . May be released into the extracellular fluid by cleavage from the cell surface. .; [FasL intracellular domain]: Nucleus . The FasL ICD cytoplasmic form is translocated into the nucleus. .
Other Product Names
FASLG; APT1LG1; CD95L; FASL; TNFSF6; Tumor necrosis factor ligand superfamily member 6; Apoptosis antigen ligand; APTL; CD95 ligand; CD95-L; Fas antigen ligand; Fas ligand; FasL; CD antigen CD178
Gene ID (Human)
356

UniProtKB · P48023

Tumor necrosis factor ligand superfamily member 6

TNFL6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P48023
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FASLG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q9BZP9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisTranscriptionTranscription regulation

Cellular component

Cell membraneCytoplasmic vesicleLysosomeMembraneNucleusSecreted

Molecular function

CytokineRepressor

PTM

Disulfide bondGlycoproteinUbl conjugation

Domain

Signal-anchorTransmembraneTransmembrane helix

Related Products

CatalogName
ES4256-01FAS rabbit pAb
ES2326-01FAS rabbit pAb
ES5864-01FAS (phospho Tyr291) rabbit pAb
ES2053-01Crk-L rabbit pAb
ES4246-01Flt3-L rabbit pAb
ES20873-01GβL Rabbit pAb
ES2552-01HnRNP L rabbit pAb
ES5686-01CD30-L rabbit pAb
ES4100-01L-Selectin rabbit pAb
ES2354-01Flt3-L rabbit pAb

Alternative Products

CatalogName
E2340387FAS-L/Fas Ligand Rabbit pAb
MBS8541701-01FAS-L Rabbit pAb
APRab10838-01FAS-L Rabbit Polyclonal Antibody
GTR18050447FAS-L rabbit pAb Antibody
A101455Anti-FAS-L (Rabbit, Polyclonal, IgG)
PAV7191Rabbit Anti-FAS-L/FASLG Polyclonal Antibody
PA85136HU-01Rabbit Anti-Human FAS-L Polyclonal Antibody
MBS8543049-01Fas Rabbit pAb
MBS9147328-01Fas Rabbit mAb
PA1101Fas-L

Popular Products