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Cyclin F rabbit pAb

CAT: 0855-ES2084-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008]
Description
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008],
UniProt
P41002
Swiss Prot
P41002
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Cyclin F. AA range:737-786
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
88kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
88kD
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Localization to the centrosome is rare in S phase cells and increases in G2 cells. Localizes to both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Localizes to the nucleus in G2 phase. .
Other Product Names
CCNF; FBX1; FBXO1; Cyclin-F; F-box only protein 1
Gene ID (Human)
899

UniProtKB · P41002

Cyclin-F

CCNF_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P41002
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CCNF
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R8H3, Q96EG9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Disease

Amyotrophic lateral sclerosisDisease variantNeurodegeneration

Biological process

Cell cycleCell divisionMitosisUbl conjugation pathway

Molecular function

Cyclin

Cellular component

CytoplasmCytoskeletonNucleus

PTM

PhosphoproteinUbl conjugation

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