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Cathepsin E rabbit pAb

CAT: 0855-ES1871-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES1871-01Size:50 µL
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Background
This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015]
Description
This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015],
UniProt
P14091
Swiss Prot
P14091
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Cathepsin E. AA range:243-292
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
48kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
48kD
Fragment
IgG
Subcellular Location
Endosome . The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.
Other Product Names
CTSE; Cathepsin E
Gene ID (Human)
1510

UniProtKB · P14091

Cathepsin E

CATE_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P14091
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CTSE
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.23.34
Processing
Precursor
Secondary accessions
Q5TZ01, Q5TZ02, Q9NY58, Q9UCE3, Q9UCE4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

Aspartyl proteaseHydrolaseProtease

PTM

Autocatalytic cleavageDisulfide bondGlycoproteinZymogen

Cellular component

Endosome

Domain

Signal

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