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Cathepsin G rabbit pAb

CAT: 0855-ES4900-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4900-01Size:50 µL
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Background
The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014]
Description
The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014],
Product Name Alternative
CTSG; Cathepsin G; CG
UniProt
P08311
Swiss Prot
P08311
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Cathepsin G. AA range:67-116
Target
Cathepsin G
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
22kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
22kD
Fragment
IgG
Subcellular Location
Cell membrane ; Peripheral membrane protein . Cytoplasmic granule . Secreted . Cytoplasm, cytosol . Lysosome . Nucleus . Secreted by activated neutrophils (PubMed:3390156) . Detected in synovial fluid (PubMed:32144329) . Localizes to lysosomes in B cells where it is not endogenously synthesized but is internalized from the cell membrane (PubMed:15100291) . Localizes to the nucleus during apoptosis (PubMed:11259672) . .
Other Product Names
CTSG; Cathepsin G; CG
Gene ID (Human)
1511

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