Bag-4 rabbit pAb

CAT: 0855-ES1745-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES1745-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct
Description
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct
UniProt
O95429
Swiss Prot
O95429
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from the C-terminal region of human Bag-4.
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
50kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
50kD
Fragment
IgG
Subcellular Location
Cytoplasm.
Other Product Names
BAG4; SODD; BAG family molecular chaperone regulator 4; BAG-4; Bcl-2-associated athanogene 4; Silencer of death domains
Gene ID (Human)
9530

Related Products

CatalogName
ES4090-01Bag-1 rabbit pAb
ES8054-01Bag-3 rabbit pAb
ES4274-01Bag-3 rabbit pAb
ES8649-01Flt-4 rabbit pAb
ES1991-01CLC-4 rabbit pAb
ES8715-01Thrombospondin 4 rabbit pAb
ES5484-01GATA-4 rabbit pAb
ES2774-01MEK-4 rabbit pAb
ES3978-01Integrin α4 rabbit pAb
ES3161-01Pdcd-4 rabbit pAb

Alternative Products

CatalogName
E28PT0441Bag-4 Rabbit Polyclonal Antibody
PAV5189Rabbit Anti-Bag-4/BAG4 Polyclonal Antibody
E2251888Bag-3 Rabbit pAb
MBS8540853-01BAG-1 Rabbit pAb
GTR10426086Rabbit BAG family molecular chaperone regulator 4 ELISA kit
APRab07434-01Bag-1 Rabbit Polyclonal Antibody
B2019572BAG-1 Rabbit Monoclonal Antibody
NBP1-89547-25ulRabbit Polyclonal Bag-1 Antibody
E28PT5544Bag-3 Rabbit Polyclonal Antibody
B2019583BAG-1L Rabbit Monoclonal Antibody

Popular Products