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PKC δ (phospho Ser645) rabbit pAb

CAT: 0855-ES1502-01Size: 50 µLDry Ice: NoHazardous: No
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Background
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Description
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008],
UniProt
Q05655
Swiss Prot
Q05655
Reactivity
Human; Monkey
Immunogen
The antiserum was produced against synthesized peptide derived from human PKC delta around the phosphorylation site of Ser645. AA range:612-661
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
77kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
77kD
Fragment
IgG
Subcellular Location
Cytoplasm . Cytoplasm, perinuclear region . Nucleus . Cell membrane ; Peripheral membrane protein . Mitochondrion . Endomembrane system . Translocates to the mitochondria upon apoptotic stimulation. Upon activation, translocates to the plasma membrane followed by partial location to the endolysosomes (PubMed:17303575) . .
Other Product Names
PRKCD; Protein kinase C delta type; Tyrosine-protein kinase PRKCD; nPKC-delta
Gene ID (Human)
5580

UniProtKB · Q05655

Protein kinase C delta type

KPCD_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q05655
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PRKCD
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.13
Processing
—
Secondary accessions
B0KZ81, B2R834, Q15144, Q86XJ6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisCell cycle

Ligand

ATP-bindingMetal-bindingNucleotide-bindingZinc

Cellular component

Cell membraneCytoplasmMembraneMitochondrionNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

Phosphoprotein

Domain

RepeatZinc-finger

Disease

Tumor suppressor

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