COX2/Cyclooxygenase 2 Mouse mAb

COX2/Cyclooxygenase 2 Mouse mAb

• Description: Prostaglandin-endoperoxide synthase 2, also known as cyclooxygenase-2 or simply COX-2, is an enzyme that in humans is encoded by the PTGS2 gene. There are two isozymes of COX encoded by distinct gene products: a constitutive COX-1 (this enzyme) and an inducible COX-2, which differ in their regulation of expression and tissue distribution. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. A splice variant of COX-1 termed COX-3 was identified in the CNS of dogs, but does not result in a functional protein in humans. Two smaller COX-1-derived proteins (the partial COX-1 proteins PCOX-1A and PCOX-1B) have also been discovered, but their precise roles are yet to be described.
• Synonyms: PTGS2 antibody, Prostaglandin H2 synthase 2 antibody, PGHS 2 antibody, Glucocorticoid-regulated inflammatory cyclooxygenase antibody
• Gene ID: 5743
• UniProt: P35354
• Cellular Locus: Endoplasmic reticulum, Membrane, Microsome
• Host: Mouse
• Species Reactivity: Human, Rat, Mouse
• Immunogen: Synthetic Peptide
• Clonality: Monoclonal
• Validated Applications: IHC
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: IHC 1:100-200
• Molecular Weight: 70kDa
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.