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CD41/Integrin α/2b Mouse mAb

CAT: 0855-EM1106-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-EM1106-02Size:100 µL
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Background
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation.
Description
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation.
Product Name Alternative
BDPLT2, CD41 antigen, CD41a, gp2b, ITGA2B, platelet fibrinogen receptor alpha
UniProt
P08514
Swiss Prot
P08514
Reactivity
Human
Immunogen
Synthetic Peptide
Clonality
Monoclonal
Source
Mouse
Applications
IHC
Concentration
1mg/mL
Dilution
IHC 1:100-200
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Fragment
IgG1
Subcellular Location
Membrane
Other Product Names
BDPLT2, CD41 antigen, CD41a, gp2b, ITGA2B, platelet fibrinogen receptor alpha
Gene ID (Human)
3674

UniProtKB · P08514

Integrin alpha-IIb

ITA2B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08514
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITGA2B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B2RCY8, O95366, Q14443, Q17R67
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Biological process

Cell adhesion

Cellular component

Cell membraneMembrane

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinPyrrolidone carboxylic acid

Disease

Disease variant

Molecular function

IntegrinReceptor

Domain

RepeatSignalTransmembraneTransmembrane helix

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