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CD68 Mouse mAb

CAT: 0855-EM1050-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-EM1050-02Size:100 µL
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Background
The CD68 antigen is a 37kD transmembrane protein that is post-translationally glycosylated to give a protein of 87-115kD. CD68 is specifically expressed by tissue macrophages, Langerhans cells and at low levels by dendritic cells. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells.
Description
The CD68 antigen is a 37kD transmembrane protein that is post-translationally glycosylated to give a protein of 87-115kD. CD68 is specifically expressed by tissue macrophages, Langerhans cells and at low levels by dendritic cells. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells.
Product Name Alternative
CD68 molecule, GP110, Macrosialin, SCARD1
UniProt
P34810
Swiss Prot
P34810
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic Peptide
Clonality
Monoclonal
Source
Mouse
Applications
IHC
Concentration
1mg/mL
Dilution
IHC 1:200
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Molecular Weight
37kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
37kDa
Fragment
IgG1
Subcellular Location
Cell membrane and Endosome membrane. Lysosome membrane
Other Product Names
CD68 molecule, GP110, Macrosialin, SCARD1
Gene ID (Human)
968

UniProtKB · P34810

Macrosialin

CD68_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P34810
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD68
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B4DVT4, Q53HR6, Q53XI3, Q96BI7
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneEndosomeLysosomeMembrane

PTM

Disulfide bondGlycoprotein

Technical term

Proteomics identificationReference proteome

Domain

RepeatSignalTransmembraneTransmembrane helix

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