Lycorine (hydrochloride)

Lycorine (hydrochloride)

• CAS Number: 2188-68-3
• UNSPSC Description: Lycorine hydrochloride is the main active ingredient of the herbal medicine derived from Lycoris radiata (L’Her.) Herb. and is also a melanoma vasculogenic inhibitor and has anti-tumor activity[1]. Lycorine hydrochloride effectively inhibits mitotic proliferation of Hey1B cells (IC50 of 1.2 μM)[2].
• Target Antigen: Autophagy; Bacterial; Virus Protease
• Type: Natural Products
• Related Pathways: Anti-infection;Autophagy
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/Lycorine-hydrochloride.html
• Purity: 99.89
• Solubility: DMSO : 125 mg/mL (ultrasonic)|H2O : 16.67 mg/mL (ultrasonic)
• Smiles: O[C@@H]1[C@@H](O)C=C(CC2)[C@@]3([H])N2CC4=C([C@@]31[H])C=C(OCO5)C5=C4.Cl
• Molecular Weight: 323.77
• References & Citations: [1]Liu, R. et al. Lycorine hydrochloride inhibits metastatic melanoma cell-dominant vasculogenic mimicry. Pigment cell & melanoma research 25, 630-638, doi:10.1111/j.1755-148X.2012.01036.x (2012).|[2]Cao, Z. et al.Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity. Toxicology letters 218, 174-185, doi:10.1016/j.toxlet.2013.01.018 (2013).bioRxiv. 2024 Feb 6:2024.02.06.579103.|Patent. US20230014181.|Ann Hematol. 2023 Mar 21.|Antiviral Res. 2024 Jul 2:228:105955.|Eur J Pharmacol. 2023 Nov 10:961:176162.|Int J Mol Med. 2022 Dec;50(6):145.|J Exp Clin Cancer Res. 2022 Mar 30;41(1):116.|Microorganisms. 2022, 10(10), 2089.|Mol Med Rep. 2024 Mar;29(3):48.|Oncol Lett. September 13, 2021.|Pharmacol Res. 2021 Dec 1;175:105985.|Research Square Preprint. 2022 Feb.|Research Square Preprint. 2022 Jan.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported